A slightly remixed part of the song was used in the David Fincher directed TV commercial for the 2006 Xbox 360 game Gears of War. The advertisement brought the song an increased level of popularity, propelling it to number one in downloads at the iTunes music store in late 2006. This song has also had a strong presence in Internet culture, as it has been used countless times for fan videos and trailers. The song was also used at the end of an episode of CSI, at the end of an episode of Jericho, and in Smallville.
The original clip: http://www.youtube.com/watch?v=9ZRib_aAQFQ
The Gary Jules clip: